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Home blood pressure monitoring in the diagnosis and treatment of hypertension in pregnancy: a systematic review and meta-analysis

Karen Tran, Raj Padwal, Nadia Khan, Mary-Doug Wright and Wee Shian Chan
June 15, 2021 9 (2) E642-E650; DOI: https://doi.org/10.9778/cmajo.20200099
Karen Tran
Division of General Internal Medicine (Tran, Khan, Chan), Department of Medicine, University of British Columbia; Centre for Health Evaluation and Outcome Sciences (Tran, Khan); and Apex Information (Wright), Vancouver, BC; Division of General Internal Medicine (Padwal), Department of Medicine, University of Alberta, Edmonton, Alta.
MD MHSc
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Raj Padwal
Division of General Internal Medicine (Tran, Khan, Chan), Department of Medicine, University of British Columbia; Centre for Health Evaluation and Outcome Sciences (Tran, Khan); and Apex Information (Wright), Vancouver, BC; Division of General Internal Medicine (Padwal), Department of Medicine, University of Alberta, Edmonton, Alta.
MD MSc
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Nadia Khan
Division of General Internal Medicine (Tran, Khan, Chan), Department of Medicine, University of British Columbia; Centre for Health Evaluation and Outcome Sciences (Tran, Khan); and Apex Information (Wright), Vancouver, BC; Division of General Internal Medicine (Padwal), Department of Medicine, University of Alberta, Edmonton, Alta.
MD MSc
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Mary-Doug Wright
Division of General Internal Medicine (Tran, Khan, Chan), Department of Medicine, University of British Columbia; Centre for Health Evaluation and Outcome Sciences (Tran, Khan); and Apex Information (Wright), Vancouver, BC; Division of General Internal Medicine (Padwal), Department of Medicine, University of Alberta, Edmonton, Alta.
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Wee Shian Chan
Division of General Internal Medicine (Tran, Khan, Chan), Department of Medicine, University of British Columbia; Centre for Health Evaluation and Outcome Sciences (Tran, Khan); and Apex Information (Wright), Vancouver, BC; Division of General Internal Medicine (Padwal), Department of Medicine, University of Alberta, Edmonton, Alta.
MD MSc
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  • Figure 1:
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    Figure 1:

    PRISMA flow diagram. Note: RCT = randomized controlled trial.

  • Figure 2:
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    Figure 2:

    Forest plots for comparison of differences in mean systolic blood pressure (SBP; panel A) and diastolic blood pressure (DBP; panel B) between home and office blood pressure measurements in pregnancy, using random effects. The mean difference was calculated as home BP – office BP. Note: CI = confidence interval, IV = inverse variance, WCH = white coat hypertension.

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    Table 1:

    Studies included in the systematic review and meta-analysis

    Author (year)†CountryStudy populationnAge, yr, mean*Baseline office BP,* mm Hg, mean ± SDBrand of monitor and validation for pregnancyNo. of measurements/wk
    Dalton et al. (1987) (20)UKHDP10Range
    28 to 39
    136 ± 17/83 ± 8Dinamap 1846, not validated4 to 28
    Mooney et al. (1991) (21)UK1 or 2 high BP readings35NA139 ± 13/74 ± 10Dinamap 1846P, not validated10
    Naef et al. (1998) (22)USHTN7NAMAP 102 ± 10Vasoplex, not validated4 to 28
    Lo et al. (2002) (23)New ZealandNormal101NA107 ± 8/66 ± 7Omron HEM-705CP, validated4 (1 d only)
    Brown et al. (2004) (24)New ZealandWCH66NA126/80Omron HEM-705CP, not validated6
    Rey et al. (2007) (25)CanadaNormal, HTN123Normal 31.4
    HTN 32.7
    127 ± 3/80 ± 2Aneroid, not validated3 to 7
    Rey et al. (2009) (26)CanadaHTN, WCH, PE159HTN 32.5
    WCH 29.6
    PE 32.2
    NAAneroid, not validated6 to 14
    Chung et al. (2009) (27)UKHDP21NANAMicrolife WatchBP, validated24
    BOSHI (2013, 2015, 2016) (17)– (19)JapanNormal53031.2Normal 108 ± 11/66 ± 9
    HTN 119 ± 13/74 ± 9
    Omron HEM-747IC, HEM7080IC, not validated7
    Denolle (2014) (28)FranceNormal4530115 ± 11/65 ± 7Hestia Pharma D2, not validated36
    Tucker et al. (2017) (29)UKHigh risk for PE16131.0117 ± 10/71 ± 9Microlife WatchBP, validated12
    Mikami et al. (2017) (30)JapanNormal10035.8114 ± 10/68 ± 6Omron 7251G, not validated14
    Lan et al. (2017) (31)AustraliaHTN3733.4NAOmron HEM-7200, not validated14
    Perry et al. (2018) (32)UKHTN16632.5NAMicrolife WatchBP, validated4 to 14
    Kalafat et al. (2018) (33)UKHTN14734134 ± 3/88 ± 3Microlife WatchBP, validatedNA
    Vestgaard et al. (2019) (34)DenmarkNormal10332115 ± 11/72 ± 7Microlife 3A Plus, validated18
    Vestgaard et al. (2019) (35)DenmarkPre-existing diabetes mellitus222WCH: 33
    HTN: 34
    Normal: 32
    WCH: 133 ± 10/87 ± 5
    HTN: 130 ± 13/84 ± 10
    Normal: 117 ± 9/74 ± 6
    Microlife 3A Plus, validated18
    Pealing et al. (2019) (36)UKHTN
    HDP
    154HTN: 35.9
    GHTN: 33.4
    HTN: 136.6 ± 13.8/85.9 ± 10.1
    GHTN: 139.5 ± 13.1/86.9 ± 9.9
    Microlife WatchBP, validated14
    Usuzaki et al. (2020) (37)JapanNormal65632.2110.5 ± 10.8/63.8 ± 8.7Omron HEM-7080IC, not validated7
    • Note: BOSHI = Babies and Their Parents’ Longitudinal Observation in Suzuki Memorial Hospital on Intrauterine Period, BP = blood pressure, GHTN = gestational hypertension, HDP = hypertensive disorders of pregnancy, HTN = hypertension, MAP = mean arterial pressure, NA = not available, PE = preeclampsia, SD = standard deviation, WCH = white coat hypertension.

    • ↵* Except where indicated otherwise.

    • ↵† All studies were observational except Pealing and colleagues. (36)

    • View popup
    Table 2:

    Summary of proposed definitions for trimester-specific upper limit of normal home blood pressure

    ReferencePopulationMethodFirst trimesterSecond trimesterThird trimester
    SBP, mm HgDBP, mm HgSBP, mm HgDBP, mm HgSBP, mm HgDBP, mm Hg
    Lo et al. (23)NormalMean ± 2 SD1328213079133/138*81/88*
    Rey et al. (25)Normal and hypertensive90th percentile139†89†13787138/140/143‡89/90/92‡
    Denolle (28)NormalMean ± 2 SD118731177312180
    Denolle (28)Normal95th percentile116701137011876
    Mikami et al. (30)NormalRegression line from standardized major axis methods120.883.5124/127§84/86§13689
    Vestgaard et al. (34)NormalMean ± 2 SD117741167312378
    • Note: DBP = diastolic blood pressure, SBP = systolic blood pressure, SD = standard deviation.

    • ↵* Blood pressure measured at 27–30 weeks and 35–37 weeks gestational age.

    • ↵† Blood pressure measured at < 20 weeks gestational age.

    • ↵‡ Blood pressure measured at 28–32 weeks, 33–36 weeks and > 36 weeks gestational age.

    • ↵§ Blood pressure measured at 12–20 weeks and 20–24 weeks gestational age.

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CMAJ Open: 9 (2)
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1 Apr 2021
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Home blood pressure monitoring in the diagnosis and treatment of hypertension in pregnancy: a systematic review and meta-analysis
Karen Tran, Raj Padwal, Nadia Khan, Mary-Doug Wright, Wee Shian Chan
Apr 2021, 9 (2) E642-E650; DOI: 10.9778/cmajo.20200099

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Home blood pressure monitoring in the diagnosis and treatment of hypertension in pregnancy: a systematic review and meta-analysis
Karen Tran, Raj Padwal, Nadia Khan, Mary-Doug Wright, Wee Shian Chan
Apr 2021, 9 (2) E642-E650; DOI: 10.9778/cmajo.20200099
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