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Impact of an emergency department opioid prescribing guideline on emergency physician behaviour and incidence of overdose in the Saskatoon Health Region: a retrospective pre–post implementation analysis

Riley J. Hartmann, Jeffrey D. Elder and Luke A. Terrett
January 29, 2021 9 (1) E79-E86; DOI: https://doi.org/10.9778/cmajo.20200071
Riley J. Hartmann
College of Medicine (Hartmann, Elder) and Department of Emergency Medicine (Hartmann, Elder, Terrett), University of Saskatchewan; Department of Adult Critical Care Medicine (Terrett), Saskatchewan Health Authority, Saskatoon, Sask.
MSc MD
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Jeffrey D. Elder
College of Medicine (Hartmann, Elder) and Department of Emergency Medicine (Hartmann, Elder, Terrett), University of Saskatchewan; Department of Adult Critical Care Medicine (Terrett), Saskatchewan Health Authority, Saskatoon, Sask.
MD
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Luke A. Terrett
College of Medicine (Hartmann, Elder) and Department of Emergency Medicine (Hartmann, Elder, Terrett), University of Saskatchewan; Department of Adult Critical Care Medicine (Terrett), Saskatchewan Health Authority, Saskatoon, Sask.
MD
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  • Figure 1:
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    Figure 1:

    Prescriber distribution of total morphine equivalents prescribed per hour worked (A) and per patient seen (B). Error bars represent standard deviation; × represents mean. Note: MME = morphine milligram equivalent.

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    Figure 2:

    Cases of opioid overdose, overdose from high-risk or unknown substances, and opioid misuse presenting to the 3 emergency departments (EDs) in the Saskatoon Health Region from January 2016 to May 2018, along with deaths from opioid overdose. Vertical dashed line denotes implementation of ED guideline for prescribing of restricted medications. *Tcodes and F11. †Includes deaths occurring in hospital only. ‡Canadian Triage and Acuity Scale levels 1–3.

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    Table 1:

    Demographic characteristics of emergency department staff physicians

    CharacteristicNo. (%) of physicians*
    n = 32
    Gender
     Male25 (78)
     Female7 (22)
    Certification
     CCFP8 (25)
     CCFP-EM18 (56)
     FRCPC-EM4 (12)
     Other2 (6)
    Average years in practice (range)12.66 (0 to 40)
    Average no. of patients seen (range)
     Before guideline implementation†980.2 (244 to 2145)
     After guideline implementation‡912.7 (136 to 2272)
    Average hours worked (range)
     Before guideline implementation†536.33 (136.00 to 966.50)
     After guideline implementation‡494.26 (87.25 to 993.25)
    Average no. of patients per hour (range)
     Before guideline implementation†1.84 (1.12 to 2.46)
     After guideline implementation‡1.84 (1.45 to 2.29)
    • Note: CCFP = Canadian College of Family Physicians, CCFP-EM = Canadian College of Family Physicians Emergency Medicine Certification, FRCPC-EM = Fellow of the Royal College of Physicians of Canada in Emergency Medicine.

    • ↵* Unless stated otherwise.

    • ↵† Nov. 1, 2015, to Apr. 30, 2016.

    • ↵‡ Nov. 1, 2016, to Apr. 30, 2017.

    • View popup
    Table 2:

    Morphine equivalents prescribed per hour worked before and after implementation of a guideline for the prescribing of restricted medications in the emergency department

    DrugBefore guideline implementation, MMEAfter guideline implementation, MMEAverage reduction (95% CI)
    AverageMedianAverageMedian
    Hydromorphone IR12.4410.918.566.59−3.88 (−5.70 to −2.05)
    Hydromorphone ER1.660.630.980.00−0.68 (−1.45 to 0.09)
    Morphine IR0.850.540.720.42−0.13 (−0.43 to 0.19)
    Morphine SR0.650.000.260.00−0.39 (−1.17 to 0.38)
    Oxycodone + acetaminophen tablets0.070.000.080.000.01 (−0.10 to 0.13)
    Acetaminophen + caffeine + codeine tablets2.842.082.621.72−0.22 (−0.95 to 0.52)
    Total18.5116.0713.2211.22−5.29 (−7.60 to −2.97)
    • Note: CI = confidence interval, ER = extended release, IR = immediate release, MME = morphine milligram equivalent, SR = sustained release.

    • View popup
    Table 3:

    Morphine equivalents prescribed per patient seen before and after implementation of the guideline

    DrugBefore guideline implementation, MMEAfter guideline implementation, MMEAverage reduction (95% CI)
    AverageMedianAverageMedian
    Hydromorphone IR6.846.244.624.14−2.22 (−3.27 to −1.17)
    Hydromorphone ER1.000.320.530.00−0.47 (−0.97 to 0.04)
    Morphine IR0.460.280.400.24−0.06 (−0.23 to 0.11)
    Morphine SR0.360.000.160.00−0.20 (−0.66 to 0.25)
    Oxycodone + acetaminophen tablets0.060.000.040.00−0.02 (−0.10 to 0.08)
    Acetaminophen + caffeine + codeine tablets1.651.251.390.99−0.26 (−0.66 to 0.14)
    Total10.368.867.146.18−3.22 (−4.81 to −1.63)
    • Note: CI = confidence interval, ER = extended release, IR = immediate release, SR = sustained release.

    • View popup
    Table 4:

    Naloxone dispensed in Saskatoon Health Region by emergency medical service and emergency department pharmacy

    VariableBefore guideline implementationAfter guideline implementation
    Prehospital naloxone given by EMS
     No. of patients treated3939
     Total drug administered, mg23.434.5
    No. of naloxone vials* dispensed to emergency departments164174
     Emergency department 1101
     Emergency department 2111134
     Emergency department 34339
    • Note: EMS = emergency medical service.

    • ↵* 2 mg/2 mL.

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CMAJ Open: 9 (1)
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1 Jan 2021
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Impact of an emergency department opioid prescribing guideline on emergency physician behaviour and incidence of overdose in the Saskatoon Health Region: a retrospective pre–post implementation analysis
Riley J. Hartmann, Jeffrey D. Elder, Luke A. Terrett
Jan 2021, 9 (1) E79-E86; DOI: 10.9778/cmajo.20200071

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Impact of an emergency department opioid prescribing guideline on emergency physician behaviour and incidence of overdose in the Saskatoon Health Region: a retrospective pre–post implementation analysis
Riley J. Hartmann, Jeffrey D. Elder, Luke A. Terrett
Jan 2021, 9 (1) E79-E86; DOI: 10.9778/cmajo.20200071
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