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Research

Impact of comprehensive hospice palliative care on end-of-life care: a propensity-score–matched retrospective observational study

Michael S.C. Conlon, Joseph M. Caswell, Andrew Knight, Barbara Ballantyne, Stacey A. Santi, Margaret L. Meigs, Craig C. Earle and Mark Hartman
April 04, 2019 7 (2) E197-E202; DOI: https://doi.org/10.9778/cmajo.20180148
Michael S.C. Conlon
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
PhD
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Joseph M. Caswell
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
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Andrew Knight
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
MD
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Barbara Ballantyne
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
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Stacey A. Santi
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
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Margaret L. Meigs
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
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Craig C. Earle
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
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Mark Hartman
Epidemiology, Outcomes and Evaluation Research (Conlon, Caswell, Santi, Meigs), Health Sciences North Research Institute; ICES North Satellite Site (Conlon, Caswell), Health Sciences North Research Institute; Northeast Cancer Centre (Knight, Ballantyne, Hartman), Health Sciences North, Sudbury, Ont.; Cancer Care Ontario (Hartman); Ontario Palliative Care Network (Knight, Ballantyne); Canadian Partnership Against Cancer (Earle), Toronto, Ont.
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    Figure 1:

    Flow chart outlining data build including linkages. Note: CIHI = Canadian Institute for Health Information, DAD = Discharge Abstract Database, NACRS = National Ambulatory Care Reporting System, OCR = Ontario Cancer Registry, OHIP = Ontario Health Insurance Plan, RPDP = Registered Persons Database, SMP = Symptom Management Program.

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    Table 1:

    Frequencies, descriptive statistics and standardized differences of each covariate before and after propensity score matching for patients who received hospice palliative care from the Symptom Management Program and a matched control group

    CovariateBefore matching; no. (%) of patients*After matching; no. (%) of patients*
    SMP
    n = 914
    Non-SMP
    n = 1613
    dSMP
    n = 754
    Non-SMP
    n = 754
    d
    Age group, yr0.580.08
     < 55101 (11.0)68 (4.2)69 (9.2)58 (7.7)
     55–64204 (22.3)180 (11.2)145 (19.2)131 (17.4)
     65–74283 (31.0)356 (22.1)234 (31.0)234 (31.0)
     ≥ 75326 (35.7)1009 (62.6)306 (40.6)331 (43.9)
    Sex0.050.00
     Male504 (55.1)926 (57.4)431 (57.2)431 (57.2)
     Female410 (44.9)687 (42.6)323 (42.8)323 (42.8)
    Charlson Comorbidity Index score, mean ± SD5.23 ± 2.823.81 ± 2.880.514.91 ± 2.834.92 ± 2.900.01
    Duration of disease, yr, mean ± SD3.45 ± 4.396.79 ± 6.350.553.79 ± 4.643.48 ± 4.230.07
    Cancer type0.440.07
     Breast59 (6.5)142 (8.8)48 (6.4)49 (6.5)
     Lung264 (28.9)225 (13.9)190 (25.2)170 (22.5)
     Colorectal96 (10.5)232 (14.4)88 (11.7)87 (11.5)
     Prostate67 (7.3)253 (15.7)65 (8.6)64 (8.5)
     Other428 (46.8)761 (47.2)363 (48.1)384 (50.9)
    Rural residence0.180.01
     No842 (92.1)1397 (86.6)688 (91.2)687 (91.1)
     Yes72 (7.9)216 (13.4)66 (8.8)67 (8.9)
    Income quintile0.140.06
     1 (lowest)208 (22.8)443 (27.5)185 (24.5)165 (21.9)
     2188 (20.6)324 (20.1)159 (21.1)163 (21.6)
     3185 (20.2)269 (16.7)143 (19.0)149 (19.8)
     4175 (19.1)327 (20.3)140 (18.6)147 (19.5)
     5 (highest)158 (17.3)250 (15.5)127 (16.8)130 (17.2)
    Index year0.150.02
     2012190 (20.8)407 (25.2)165 (21.9)166 (22.0)
     2013232 (25.4)436 (27.0)203 (26.9)210 (27.8)
     2014228 (24.9)397 (24.6)188 (24.9)183 (24.3)
     2015264 (28.9)373 (23.1)198 (26.3)195 (25.9)
    • Note: d = standardized difference, SD = standard deviation, SMP = Symptom Management Program.

    • ↵* Except where noted otherwise.

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    Table 2:

    Study outcomes related to the use of aggressive end-of-life care in the 2 groups

    OutcomeGroup; no. (%) of patientsAbsolute risk reduction (95% CI)Number needed to treat (95% CI)RR (95% CI)
    SMPNon-SMP
    Hospital admission36 (4.8)57 (7.6)2.79 (2.76–2.82)36 (35.45–36.25)0.63 (0.42–0.95)
    Emergency department visit71 (9.4)99 (13.1)3.71 (3.66–3.76)27 (26.57–27.35)0.72 (0.53–0.97)
    Chemotherapy11 (1.5)19 (2.5)–––
    Intensive care unit admission8 (1.1)92 (12.2)11.14 (11.11–11.17)9 (8.95–9.00)0.09 (0.04–0.18)
    Any aggressive end-of-life care94 (12.5)190 (25.2)12.73 (12.65–12.81)8 (7.81–7.91)0.50 (0.39–0.62)
    Death in acute care182 (24.1)332 (44.0)19.89 (19.78–20.00)5 (5.00–5.06)0.55 (0.47–0.64)
    • Note: CI = confidence interval, RR = relative risk, SMP = Symptom Management Program.

    • View popup
    Table 3:

    Descriptive statistics and results for FAMCARE questionnaire completed by family members of patients who received hospice palliative care from the Symptom Management Program

    Subscale (no. of items/maximum score)Overall; mean score ± SD
    n = 96
    Aggressive end-of-life care (any); mean score ± SDp valueDeath in acute care; mean score ± SDp value
    No
    n = 86
    Yes
    n = 10
    No
    n = 68
    Yes
    n = 28
    Information giving (5/25)21.03 ± 3.3921.26 ± 3.4119.10 ± 2.600.0220.88 ± 3.7021.39 ± 2.500.95
    Physical patient care (7/35)29.98 ± 3.8830.17 ± 3.8428.30 ± 3.970.129.75 ± 4.1830.54 ± 3.010.6
    Psychosocial care (4/20)17.24 ± 2.4317.41 ± 2.4115.80 ± 2.150.0417.25 ± 2.5917.21 ± 2.030.7
    Availability of care (4/20)17.47 ± 2.5317.66 ± 2.4015.80 ± 3.120.0217.34 ± 2.8017.79 ± 1.750.8
    Total (20/100)85.72 ± 11.1186.50 ± 10.9379.00 ± 10.940.0385.22 ±12.0986.93 ± 8.320.8
    • Note: SD = standard deviation.

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CMAJ Open: 7 (2)
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Impact of comprehensive hospice palliative care on end-of-life care: a propensity-score–matched retrospective observational study
Michael S.C. Conlon, Joseph M. Caswell, Andrew Knight, Barbara Ballantyne, Stacey A. Santi, Margaret L. Meigs, Craig C. Earle, Mark Hartman
Apr 2019, 7 (2) E197-E202; DOI: 10.9778/cmajo.20180148

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Impact of comprehensive hospice palliative care on end-of-life care: a propensity-score–matched retrospective observational study
Michael S.C. Conlon, Joseph M. Caswell, Andrew Knight, Barbara Ballantyne, Stacey A. Santi, Margaret L. Meigs, Craig C. Earle, Mark Hartman
Apr 2019, 7 (2) E197-E202; DOI: 10.9778/cmajo.20180148
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