Cause-specific mortality among HIV-infected people in Ontario, 1995–2014: a population-based retrospective cohort study

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Figure 1
All-cause (A) and cause-specific (B) age-adjusted mortality rate per 100 person-years among HIV-infected people in Ontario, 1995–2014.

Table 1

Characteristics of HIV-infected people at the start of follow-up, Ontario, 1995–2014

Characteristic	No. (%) of people^* n = 23 043
Year of presentation for HIV infection care
1994 or earlier	5647 (24.5)
1995–1999	4827 (20.9)
2000–2004	4188 (18.2)
2005–2009	4541 (19.7)
2010–2014	3840 (16.7)
Age at start of follow up, yr, mean ± SD	37.89 ± 11.2
Age at start of follow up, yr
≤ 25	2366 (10.3)
26–35	8454 (36.7)
36–45	7425 (32.2)
46–55	3212 (13.9)
≥ 56	1586 (6.9)
Female sex	4360 (18.9)
Urban/rural residence
Major urban centre	20 625 (89.5)
Nonmajor urban centre	1509 (6.5)
Rural	595 (2.6)
Missing	314 (1.4)
Neighbourhood income quintile
1 (lowest)	7165 (31.1)
2	4789 (20.8)
3	3845 (16.7)
4	3285 (14.2)
5 (highest)	3387 (14.7)
Missing	572 (2.5)
Immigrant status
Long-term resident^†	18 891 (82.0)
Immigrant from nonendemic country	1735 (7.5)
Immigrant from country with generalized HIV infection epidemic	2417 (10.5)

Table 2

Age-adjusted all-cause and cause-specific mortality rates per 100 person-years among HIV-infected people in Ontario, 1995–2014

Cause of death	1995–1999		2000–2004		2005–2009		2010–2014

	No. (%) of deaths	Mortality rate per 100 person-years^* (95% CI)	No. (%) of deaths	Mortality rate per 100 person-years^* (95% CI)	No. (%) of deaths	Mortality rate per 100 person-years^* (95% CI)	No. (%) of deaths	Mortality rate per 100 person-years^* (95% CI)
Any	1895 (100.0)	6.69 (6.22–7.19)	1024 (100.0)	2.81 (2.57–3.06)	1081 (100.0)	2.11 (1.95–2.27)	1015 (100.0)	1.53 (1.42–1.64)

HIV/AIDS	1506 (79.5)	4.75 (4.39–5.14)	619 (60.4)	1.46 (1.30–1.63)	602 (55.7)	0.99 (0.89–1.09)	353 (34.8)	0.46 (0.41–0.52)

Other communicable disease	50 (2.6)	0.21 (0.13–0.32)	24 (2.3)	0.05 (0.03–0.09)	30 (2.8)	0.06 (0.04–0.10)	68 (6.7)	0.10 (0.07–0.13)

Cardiovascular disease	56 (3.0)	0.39 (0.32–0.47)	69 (6.7)	0.23 (0.19–0.27)	73 (6.8)	0.20 (0.15–0.26)	124 (12.2)	0.23 (0.19–0.28)

Malignant neoplasm	75 (4.0)	0.53 (0.37–0.71)	97 (9.5)	0.36 (0.27–0.47)	155 (14.3)	0.39 (0.32–0.47)	183 (18.0)	0.29 (0.24–0.34)

Other noncommunicable disease	82 (4.3)	0.44 (0.31–0.6)	79 (7.7)	0.28 (0.20–0.38)	99 (9.2)	0.26 (0.21–0.33)	149 (14.7)	0.24 (0.20–0.29)

Injury	76 (4.0)	0.19 (0.13–0.28)	96 (9.4)	0.19 (0.14–0.24)	87 (8.0)	0.14 (0.10–0.18)	96 (9.4)	0.14 (0.11–0.17)

Unavailable or ill-defined	50 (2.6)	0.18 (0.11–0.27)	40 (3.9)	0.13 (0.08–0.19)	35 (3.2)	0.06 (0.04–0.10)	42 (4.1)	0.07 (0.05–0.09)