Skip to main content

Main menu

  • Home
  • Content
    • Current issue
    • Past issues
    • Collections
  • About
    • General information
    • Staff
    • Editorial board
    • Open access
    • Contact
  • CMAJ JOURNALS
    • CMAJ
    • CJS
    • JAMC
    • JPN

User menu

Search

  • Advanced search
CMAJ Open
  • CMAJ JOURNALS
    • CMAJ
    • CJS
    • JAMC
    • JPN
CMAJ Open

Advanced Search

  • Home
  • Content
    • Current issue
    • Past issues
    • Collections
  • About
    • General information
    • Staff
    • Editorial board
    • Open access
    • Contact
  • RSS feeds
Research

Causes and consequences of gestational diabetes in South Asians living in Canada: results from a prospective cohort study

Sonia S. Anand, Milan Gupta, Koon K. Teo, Karleen M. Schulze, Dipika Desai, Nora Abdalla, Michael Zulyniak, Russell de Souza, Gita Wahi, Mateen Shaikh, Joseph Beyene, Eileen de Villa, Katherine Morrison, Sarah D. McDonald, Hertzel Gerstein and for the South Asian Birth Cohort (START) - Canada Investigators
August 10, 2017 5 (3) E604-E611; DOI: https://doi.org/10.9778/cmajo.20170027
Sonia S. Anand
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Milan Gupta
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Koon K. Teo
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MBBCh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karleen M. Schulze
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MMath
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dipika Desai
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MSc
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nora Abdalla
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MBBCh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Zulyniak
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Russell de Souza
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
BA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gita Wahi
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mateen Shaikh
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph Beyene
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eileen de Villa
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katherine Morrison
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah D. McDonald
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hertzel Gerstein
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Departments of Medicine (Anand, Teo, Zulyniak, Gerstein), Health Research Methods, Evidence and Impact(Shaikh, de Souza, Beyene), Pediatrics(Wahi, Morrison) and Obstetrics and Gynecology(McDonald), McMaster University; Population Health Research Institute (Anand, Teo); Hamilton Health Sciences (Anand, Teo, Schulze, Desai, Abdalla), Hamilton, Ont.; Canadian Cardiovascular Research Network (Gupta), Brampton, Ont.; Peel Public Health (de Villa), Mississauga, Ont.
  • Article
  • Figures & Tables
  • Related Content
  • Responses
  • Metrics
  • PDF
Loading

Article Figures & Tables

Figures

  • Tables
  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1

    Partial proportional attributable risk for individual risk factors for the development of gestational diabetes mellitus among South Asian women. Error bars represent 95% confidence intervals. Note: BMI = body mass index.

Tables

  • Figures
    • View popup
    Table 1: Foods in low- versus high-quality diet among South Asians in pregnancy25
    Foods consumed in greater quantity in low-quality dietFoods consumed in greater quantity in high-quality diet
    Meat, meat dishes, processed meats, organ meats, poultryVegetables, raw and cooked
    Fish, seafoodLegumes (daals)
    RiceNuts and seeds
    Fried foodsLow-fat dairy products (low-fat and fermented)
    Refined grains (breads and cereals)Whole grains (breads and cereals)
    Fast foodsSweets
    EggsFruits
    • View popup
    Table 2: Characteristics of participants with and without gestational diabetes mellitus*
    CharacteristicMean ± SD†p value
    Gestational diabetes‡
    n = 365
    No gestational diabetes
    n = 641
    Age, yr31.2 ± 4.029.7 ± 3.8< 0.001
    Length of time in Canada, yr8.8 ± 7.58.2 ± 7.90.2
    Duration of pregnancy at study enrolment, wk26.8 ± 2.126.6 ± 1.60.1
    Parity, no. (%)
        Primiparous123 (33.7)283 (44.1)< 0.001
        Multiparous236 (64.6)343 (53.5)
        Unknown6 (1.6)15 (2.3)
    Smoked during pregnancy, no. (%)0 (0.0)2 (0.3)0.5
    Vegetarian, no. (%)125 (34.5)243 (38.1)0.2
    Diet quality score2.2 ± 1.42.5 ± 1.30.002
    Low diet quality, no. (%)121 (33.4)145 (22.9)< 0.001
    Time spent engaged in active sport per wk, h1.4 ± 2.21.6 ± 2.50.4
    Physical activity in pregnancy, no. (%)
        Sedentary97 (26.6)139 (21.7)0.2
        Mild exercise202 (55.3)373 (58.2)
        Moderate exercise64 (17.5)128 (20.0)
        Unknown2 (0.5)1 (0.2)
    Family history of diabetes, no. (%)191 (52.5)228 (35.7)< 0.001
    Social disadvantage index, no. (%)
        High47 (12.9)90 (14.0)0.9
        Moderate118 (32.3)213 (33.2)
        Low145 (39.7)251 39.2)
        Unknown55 (15.1)87 (13.6)
    Currently employed, no. (%)196 (54.0)349 (54.5)0.9
    Annual household income ≥ $50 000, no. (%)143 (46.0)242 (43.6)0.5
    High school education, no. (%)361 (99.4)638 (99.5)0.9
    Prepregnancy weight, kg64.9 ± 12.261.3 ± 11.8< 0.001
    Height, cm161.6 ± 6.2162.5 ± 6.30.02
    Prepregnancy body mass index24.9 ± 4.623.2 ± 4.3< 0.001
    Sum of skinfold measurements at enrolment, mm52.3 ± 12.347.9 ± 12.4< 0.001
    Triceps skinfold thickness at enrolment, mm28.5 ± 6.726.5 ± 6.8< 0.001
    Subscapular skinfold thickness at enrolment, mm24.1 ± 6.621.5 ± 6.5< 0.001
    Glucose area under the curve, mmol/min966.8 ± 164.0722.4 ± 102.5< 0.001
    Weight gain during pregnancy, kg13.5 ± 7.514.7 ± 7.90.02
    Weight gain during pregnancy/prepregnancy weight0.22 ± 0.130.25 ± 0.15< 0.001
    Cesarean delivery, no. (%)127 (35.2)177 (27.9)0.02

    Note: SD = standard deviation.

    *Data missing for some variables.

    †Except where noted otherwise.

    ‡Classified with the cut-off values derived from the Born in Bradford cohort.26 Participants with a history of diabetes were excluded.

      • View popup
      Table 3: Population attributable risk for gestational diabetes
      Risk factorOR (95% CI) from multivariable modelPrevalence, %Population attributable risk % (95% CI)*
      Age 32-43 yr v. < 29 yr2.10 (1.51 to 2.91)36.424.5 (15.2 to 33.7)
      Age 29-31 yr v. < 29 yr1.34 (0.94 to 1.90)28.67.0 (-1.1 to 15.0)
      Family history of diabetes mellitus 1.70 (1.29 to 2.23)42.121.6 (11.4 to 31.8)
      Low diet quality1.62 (1.20 to 2.19)26.712.8 (5.2 to 20.4)
      Body mass index > 23 v. ≤ 231.80 (1.37 to 2.37)51.528.1 (16.6 to 39.5)
      Low diet quality and/or body mass index > 2363.537.3 (25.9 to 48.7)
      All factors65.3 (55.6 to 75.1)

      Note: CI = confidence interval, OR = odds ratio.

      *Continuous factors needed to be categorized: age was divided into tertiles, and body mass index was split into 3 categories (< 18.5, 18.5-23 and > 23); the highest category was selected as it was significantly different from the lower categories.

        • View popup
        Table 4: Newborn characteristics by maternal gestational diabetes status
        CharacteristicMean ± SE*†p value
        Gestational diabetes*
        n = 359
        No gestational diabetes
        n = 630
        Male, no. (%)188 (52.4)304 (48.2)
        Gestational age, wk38.8 ± 1.639.3 ± 1.4
        Size for gestational age,‡ no. (%)
            Large48 (13.4)55 (8.7)0.02
            Average277 (77.2)493 (78.2)
            Small24 (6.7)64 (10.2)
            Unknown10 (2.8)18 (2.8)
        Birth weight, g3267 ± 233181 ± 170.005
        Length, cm51.0 ± 0.151.1 ± 0.10.7
        Waist circumference, cm30.8 ± 0.130.3 ± 0.10.009
        Head circumference, cm34.1 ± 0.134.0 ± 0.10.4
        Sum of skinfold measurements, mm11.7 ± 0.111.2 ± 0.10.007
        Triceps skinfold thickness, mm6.1 ± 0.15.9 ± 0.10.05
        Subscapular skinfold thickness, mm5.5 ± 0.15.2 ± 0.10.002
        Ponderal index§24.8 ± 0.224.0 ± 0.10.002
        Placental weight, g503.2 ± 8.1474.9 ± 5.80.007
        Cord blood glucose level, mmol/L4.1 ± 0.14.1 ± 0.00.9
        Cord blood insulin (log) level, pmol/L76.3 ± 3.861.6 ± 2.80.002
        Glucose/insulin ratio, mmol/pmol¶0.092 ± 0.0090.129 ± 0.0060.001

        Note: SE = standard error.

        *Except where noted otherwise.

        †Adjusted for gestational age, sex and insulin use by mother during pregnancy.

        ‡Determined from gestational age and sex-specific percentiles from study data.

        §Birth weight (kg)/birth length (m3).

        ¶Non log insulin level used.

        PreviousNext
        Back to top

        In this issue

        CMAJ Open: 5 (3)
        Vol. 5, Issue 3
        25 Sep 2017
        • Table of Contents
        • Index by author

        Article tools

        Respond to this article
        Print
        Download PDF
        Article Alerts
        To sign up for email alerts or to access your current email alerts, enter your email address below:
        Email Article

        Thank you for your interest in spreading the word on CMAJ Open.

        NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

        Enter multiple addresses on separate lines or separate them with commas.
        Causes and consequences of gestational diabetes in South Asians living in Canada: results from a prospective cohort study
        (Your Name) has sent you a message from CMAJ Open
        (Your Name) thought you would like to see the CMAJ Open web site.
        CAPTCHA
        This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
        Citation Tools
        Causes and consequences of gestational diabetes in South Asians living in Canada: results from a prospective cohort study
        Sonia S. Anand, Milan Gupta, Koon K. Teo, Karleen M. Schulze, Dipika Desai, Nora Abdalla, Michael Zulyniak, Russell de Souza, Gita Wahi, Mateen Shaikh, Joseph Beyene, Eileen de Villa, Katherine Morrison, Sarah D. McDonald, Hertzel Gerstein, for the South Asian Birth Cohort (START) - Canada Investigators
        Aug 2017, 5 (3) E604-E611; DOI: 10.9778/cmajo.20170027

        Citation Manager Formats

        • BibTeX
        • Bookends
        • EasyBib
        • EndNote (tagged)
        • EndNote 8 (xml)
        • Medlars
        • Mendeley
        • Papers
        • RefWorks Tagged
        • Ref Manager
        • RIS
        • Zotero
        Share
        Causes and consequences of gestational diabetes in South Asians living in Canada: results from a prospective cohort study
        Sonia S. Anand, Milan Gupta, Koon K. Teo, Karleen M. Schulze, Dipika Desai, Nora Abdalla, Michael Zulyniak, Russell de Souza, Gita Wahi, Mateen Shaikh, Joseph Beyene, Eileen de Villa, Katherine Morrison, Sarah D. McDonald, Hertzel Gerstein, for the South Asian Birth Cohort (START) - Canada Investigators
        Aug 2017, 5 (3) E604-E611; DOI: 10.9778/cmajo.20170027
        Twitter logo Facebook logo Mendeley logo
        • Tweet Widget
        • Facebook Like

        Related Articles

        • PubMed
        • Google Scholar

        Cited By...

        • A culturally tailored personaliseD nutrition intErvention in South ASIan women at risk of Gestational Diabetes Mellitus (DESI-GDM): a randomised controlled trial protocol
        • Barriers and facilitators to healthy active living in South Asian families in Canada: a thematic analysis
        • The Genetic Risk of Gestational Diabetes in South Asian women
        • Unique Metabolic Profiles Associate with Gestational Diabetes and Ethnicity in Low and High-Risk Women Living in the UK
        • Serum metabolomic signatures of gestational diabetes in South Asian and white European women
        • Associations between maternal characteristics and pharmaceutical treatment of gestational diabetes: an analysis of the UK Born in Bradford (BiB) cohort study
        • Genome-Wide Polygenic Risk Scores and Prediction of Gestational Diabetes in South Asian Women
        • Google Scholar

        Similar Articles

        Content

        • Current issue
        • Past issues
        • Collections

        About

        • General Information
        • Staff
        • Editorial Board
        • Advisory Panel
        • Contact Us
        • Reprints
        • Copyright and Permissions
        CMAJ Group

        Copyright 2025, CMA Impact Inc. or its licensors. All rights reserved. ISSN 2291-0026

        All editorial matter in CMAJ OPEN represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.

        To receive any of these resources in an accessible format, please contact us at CMAJ Group, 500-1410 Blair Towers Place, Ottawa ON, K1J 9B9; p: 1-888-855-2555; e: [email protected].

        CMA Civility, Accessibility, Privacy

         

         

        Powered by HighWire