Article Figures & Tables
Figures
- Figure 1:
(A) Average yearly rate of community-acquired rotavirus admissions per 10 000 hospital admissions and (B) average yearly rate of hospital-acquired rotavirus infections per 1000 patient-days by province from 2005 to 2020, in the pre- and post-vaccine periods, excluding year of program implementation (year 0).
- Figure 2:
(A) Average yearly rate of community-acquired rotavirus admissions per 10 000 hospital admissions and (B) average yearly rate of hospital-acquired rotavirus infections per 1000 patient-days by age group from 2005 to 2020, in the pre- and post-vaccine periods, excluding year of program implementation (year 0).
Tables
- Table 1:
Dates of introduction for publicly funded rotavirus immunization programs in Canada by province with and without IMPACT sites
Province or territory Date Designated year 0 With IMPACT sites Ontario (2 sites: Hospital for Sick Children, Toronto, and Children’s Hospital of Eastern Ontario, Ottawa) August 2011 2011 Québec (3 sites: CHU Sainte-Justine, Montréal; Montréal Children’s Hospital, Montréal; and CHU Laval–Centre mère-enfant Soleil, Québec) November 2011 2012 British Columbia (1 site: BC Children’s Hospital) January 2012 2012 Saskatchewan (1 site: Jim Pattison Children’s Hospital, Saskatoon) November 2012 2013 Manitoba (1 site: The Children’s Hospital of Winnipeg, Winnipeg) April 2014 2014 Alberta (2 sites: Stollery Children’s Hospital, Edmonton, and Alberta Children’s Hospital, Calgary) June 2015 2015 Newfoundland (1 site: Eastern Health Janeway Child Health and Rehabilitation Centre, St. John’s) September 2015 2015 Nova Scotia (1 site: IWK Health Centre, Halifax) November 2019 2020 Without IMPACT sites Prince Edward Island December 2010 NA New Brunswick May 2018 NA Northwest Territories Fall 2013 NA Nunavut December 2017 NA Yukon October 2012 NA Note: CHU = centre hospitalier universitaire; IMPACT = Immunization Monitoring Program, Active; NA = not applicable.
- Table 2:
Ages of patients with community-acquired rotavirus infections admitted to hospital or hospital-acquired rotavirus infection in the pre-vaccine versus post-vaccine time periods*
Age No. (%) of patients in pre-vaccine program period† No. (%) of patients in post-vaccine program period† Communityacquired
n = 3331Hospitalacquired
n = 1109Total
n = 4440Communityacquired
n = 656Hospitalacquired
n = 162Total
n = 818Age, yr, mean 2.3 2.0 2.2 3.4 2.8 3.0 Age, yr, median (IQR) 1.5 (0.8–2.7) 0.8 (0.3–1.8) 1.3 (0.6–2.5) 2.4 (1.1–4.9) 1.0 (0.2–3.4) 1.8 (0.8–3.8) Age group 0–11 mo 1118 (33.5) 648 (58.4) 1766 (39.8) 161 (24.6) 79 (48.8) 240 (29.3) 12–23 mo 1027 (30.8) 209 (18.8) 1236 (27.8) 129 (19.7) 26 (16.0) 155 (19) 24–59 mo 833 (25.0) 133 (12.0) 966 (21.8) 207 (31.6) 27 (16.7) 234 (28.6) 5–9 yr 243 (7.3) 56 (5.0) 299 (6.7) 126 (19.2) 15 (9.2) 141 (17.2) 10–16 yr 110 (3.3) 63 (5.7) 173 (3.9) 33 (5.0) 15 (9.2) 48 (5.9) - Table 3:
Comparison of clinical presentations and hospital admission for patients with community-acquired rotavirus infections (2008–2020) in the pre-vaccine and post-vaccine periods, excluding those from year of vaccine implementation (year 0)
Characteristic No. (%) of patients Pre-vaccine period
n = 1972Post-vaccine period
n = 656Clinical presentations Diarrhea, vomiting and fever 1466 (74) 408 (62) Dehydration 1594 (81) 509 (78) Electrolyte abnormalities 920 (47) 282 (43) Shock† 37 (2) 20 (3) Seizures 145 (7) 54 (8) IV hydration 1906 (97) 624 (95) Hospital admission ICU admission 75 (3.8) 38 (5.7) Days in ICU, median (IQR) 2 (1–4) 1 (1–3) Length of hospital stay, d, median (IQR) 2 (2–4) 3 (2–5) Note: ICU = intensive care unit, IQR = interquartile range, IV = intravenous.
* Unless otherwise indicated.
↵† Shock criteria included low blood pressure and tachycardia.
- Table 4:
Average rates of hospital admission for community-acquired rotavirus infection and hospital-acquired rotavirus infection among age groups that were not eligible for the vaccine in the pre- and post-vaccine periods
Variable Rate Average decrease in rate, % Pre-vaccine period Post-vaccine period Average admission rate for community-acquired infections per 10 000 hospital admissions Age group 24–59 mo 15.4 1.4 91 5–9 yr 6.1 1.6 74 10–16 yr 2.3 0.5 76 Average rate of hospital-acquired infections per 1000 patient-days Age group 24–59 mo 0.054 0.003 95 5–9 yr 0.022 0.003 85 10–16 yr 0.012 0.005 61
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