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Telemedicine use and outcomes after transient ischemic attack and minor stroke during the COVID-19 pandemic: a population-based cohort study

Amy Y.X. Yu, Jeremy Penn, Peter C. Austin, Douglas S. Lee, Joan Porter, Jiming Fang, Donald A. Redelmeier and Moira K. Kapral
October 04, 2022 10 (4) E865-E871; DOI: https://doi.org/10.9778/cmajo.20220027
Amy Y.X. Yu
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
MD MSc
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Jeremy Penn
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
BHSc
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Peter C. Austin
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
PhD
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Douglas S. Lee
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
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Joan Porter
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
MSc
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Jiming Fang
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
PhD
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Donald A. Redelmeier
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
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Moira K. Kapral
Division of Neurology (Yu, Penn), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; ICES Central (Yu, Austin, Lee, Porter, Fang, Kapral); Division of Cardiology (Lee), Department of Medicine, University of Toronto, University Health Network; Division of General Internal Medicine (Redelmeier), Department of Medicine, University of Toronto, Sunnybrook Health Sciences Centre; Division of General Internal Medicine (Kapral), Department of Medicine, University of Toronto, University Health Network, Toronto, Ont.
MD MSc
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  • Figure 1:
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    Figure 1:

    Age–sex standardized rates and standard error of emergency department visits for transient ischemic attack or ischemic stroke per 100 000 discharged without admission.

  • Figure 2:
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    Figure 2:

    Pattern of clinic visits within 90 days of emergency department discharge for transient ischemic attack or minor stroke.

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    Figure 3:

    Forest plot of the risk difference (RD) and 95% confidence interval (CI) of clinic visits, stroke investigations and medication refills after the implementation of telemedicine compared with before. Note: ED = emergency department.

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    Table 1:

    Patient characteristics before and after the implementation of outpatient telemedicine billing codes

    CharacteristicNo. (%) of patients*Std. diff.†
    Apr. 1, 2015, to Mar. 31, 2020
    n = 40 098
    Apr. 1, 2020, to Mar. 31, 2021
    n = 7503
    Age, yr, median (IQR)73 (62–82)73 (62–81)0.024
    Sex, female19 786 (49.3)3682 (49.1)0.005
    Neighbourhood income quintile
     1 (lowest)8583 (21.4)1465 (19.5)0.047
     28479 (21.1)1540 (20.5)0.015
     38035 (20.0)1506 (20.1)0.001
     47334 (18.3)1436 (19.1)0.022
     5 (highest)7536 (18.8)1532 (20.4)0.041
     Missing131 (0.3)24 (0.3)0.001
    Residence
     Large urban (population > 100 000)29 832 (74.4)5485 (73.1)0.029
     Medium urban (population 10 000–100 000)4512 (11.3)848 (11.3)0.002
     Small town (population < 10 000)5754 (14.3)1170 (15.6)0.035
    Most responsible diagnosis
     Ischemic stroke10 035 (25.0)1871 (24.9)0.002
     Transient ischemic attack30 063 (75.0)5632 (75.1)0.002
    ED hospital type
     Comprehensive stroke centre8041 (20.1)1758 (23.4)0.082
     Primary stroke centre7002 (17.5)1458 (19.4)0.051
     Nondesignated stroke centre25 055 (62.5)4287 (57.1)0.109
    Hypertension28 239 (70.4)4995 (66.6)0.083
    Diabetes12 458 (31.1)2367 (31.5)0.010
    Atrial fibrillation7015 (17.5)1203 (16.0)0.039
    Dyslipidemia16 028 (40.0)2880 (38.4)0.033
    History of stroke4202 (10.5)715 (9.5)0.032
    Coronary artery disease5915 (14.8)984 (13.1)0.047
    Peripheral artery disease1374 (3.4)194 (2.6)0.049
    Baseline medication use
     Antihypertensive20 652 (51.5)3827 (51.0)0.010
     Antihyperlipidemic17 320 (43.2)3388 (45.2)0.039
     Antihyperglycemic5737 (14.3)1146 (15.3)0.027
    • Note: ED = emergency department, IQR = interquartile range.

    • ↵* Unless stated otherwise.

    • ↵† Std. diff.: standardized difference, where value > 0.1 indicates a potentially meaningful difference.

    • View popup
    Table 2:

    Admission and death within 90 days of emergency department discharge before and after the implementation of outpatient telemedicine billing codes

    VariableNo. (%) of patientsRate (95% CI) per 100 person-monthAdjusted HR* (95% CI)
    Apr. 1, 2015, to Mar. 31, 2020
    n = 40 098
    Apr. 1, 2020, to Mar. 31, 2021
    n = 7503
    Apr. 1, 2015, to Mar. 31, 2020
    n = 40 098
    Apr. 1, 2020, to Mar. 31, 2021
    n = 7503
    All-cause admission6216 (15.5)1107 (14.8)5.9 (5.7 to 6.0)5.6 (5.3 to 5.9)0.97 (0.91 to 1.04)
    Stroke admission1567 (3.9)311 (4.1)1.4 (1.3 to 1.4)1.5 (1.3 to 1.6)1.06 (0.94 to 1.20)
    Death1141 (2.8)220 (2.9)1.0 (0.9 to 1.0)1.0 (0.9 to 1.1)1.07 (0.93 to 1.24)
    • Note: CI = confidence interval, HR = hazard ratio.

    • ↵* Adjusted for age (continuous), sex, neighbourhood income, rurality, most responsible diagnosis (transient ischemic attack v. stroke), hypertension, diabetes, atrial fibrillation, dyslipidemia, history of stroke, coronary artery disease and peripheral artery disease.

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CMAJ Open: 10 (4)
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1 Oct 2022
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Telemedicine use and outcomes after transient ischemic attack and minor stroke during the COVID-19 pandemic: a population-based cohort study
Amy Y.X. Yu, Jeremy Penn, Peter C. Austin, Douglas S. Lee, Joan Porter, Jiming Fang, Donald A. Redelmeier, Moira K. Kapral
Oct 2022, 10 (4) E865-E871; DOI: 10.9778/cmajo.20220027

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Telemedicine use and outcomes after transient ischemic attack and minor stroke during the COVID-19 pandemic: a population-based cohort study
Amy Y.X. Yu, Jeremy Penn, Peter C. Austin, Douglas S. Lee, Joan Porter, Jiming Fang, Donald A. Redelmeier, Moira K. Kapral
Oct 2022, 10 (4) E865-E871; DOI: 10.9778/cmajo.20220027
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