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Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial

Vincent I. Lau, Robert Fowler, Ruxandra Pinto, Alain Tremblay, Sergio Borgia, François M. Carrier, Matthew P. Cheng, John Conly, Cecilia T. Costiniuk, Peter Daley, Erick Duan, Madeleine Durand, Patricia S. Fontela, George Farjou, Mike Fralick, Anna Geagea, Jennifer Grant, Yoav Keynan, Kosar Khwaja, Nelson Lee, Todd C. Lee, Rachel Lim, Conar R. O’Neil, Jesse Papenburg, Makeda Semret, Michael Silverman, Wendy Sligl, Ranjani Somayaji, Darrell H.S. Tan, Jennifer L.Y. Tsang, Jason Weatherald, Cedric Philippe Yansouni, Ryan Zarychanski and Srinivas Murthy; for the E-CATCO authors, AMMI Clinical Research Network and Canadian Critical Care Trials Group
September 06, 2022 10 (3) E807-E817; DOI: https://doi.org/10.9778/cmajo.20220077
Vincent I. Lau
Department of Critical Care Medicine (Lau, Sligl), Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, Edmonton, Alta.; Interdepartmental Division of Critical Care Medicine (Fowler), University of Toronto; Department of Critical Care Medicine (Pinto), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Respiratory Medicine (Tremblay, Lim, Weatherald), Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Borgia), William Osler Health System, Brampton, Ont.; Division of Infectious Diseases (Borgia), Department of Medicine, McMaster University, Hamilton, Ont.; Division of Critical Care Medicine (Carrier), Departments of Anesthesiology and Medicine, Centre hospitalier de l’Université de Montréal; Infectious Diseases and Medical Microbiology (Cheng), Department of Medicine, McGill University Health Centre, Montréal, Que.; Section of Infectious Diseases (Conly, Somayaji), Department of Medicine, Cumming School of Medicine, University of Calgary and Alberta Health Services, Calgary, Alta.; Division of Infectious Diseases and Chronic Viral Illness Service (Costiniuk), Department of Medicine, McGill University Health Centre, Montréal, Que.; Department of Medicine and Laboratory Medicine (Daley), Memorial University, St. John’s, NL; Division of Critical Care (Duan, Tsang), Department of Medicine, McMaster University, Hamilton, Ont.; Department of Medicine (Duan, Tsang), Niagara Health, St. Catharines, Ont.; Department of Critical Care (Duan), St. Joseph’s Healthcare, Hamilton, Ont.; Internal Medicine Service (Durand), Centre hospitalier de l’Université de Montréal; Division of Pediatric Critical Care (Fontela), Department of Pediatrics, McGill University, Montréal, Que.; Division of Infectious Disease (Farjou), Department of Medicine, Niagara Health, St. Catharines, Ont.; Department of Medicine (Fralick, Semret), Sinai Health, University of Toronto; Division of Critical Care Medicine (Geagea), Department of Medicine, North York General Hospital, Toronto, Ont.; Division of Medical Microbiology and Infectious Diseases (Grant), Department of Medicine, University of British Columbia, Vancouver, BC; Section of Infectious Diseases (Keynan), Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Man.; Departments of Surgery and Critical Care Medicine (Khwaja), McGill University, Montréal, Que.; Dalla Lana School of Public Health (N. Lee), University of Toronto, Toronto, Ont.; Clinical Practice Assessment Unit (T. Lee), Department of Medicine, McGill University, Montréal, Que.; Division of Infectious Diseases (O’Neil), Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta.; Division of Pediatric Infectious Diseases (Papenburg), Department of Pediatrics, Montreal Children’s Hospital; Division of Microbiology (Papenburg), Department of Clinical Laboratory Medicine, McGill University Health Centre, Montréal, Que.; Division of Infectious Diseases (Silverman), Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont.; Division of Infectious Diseases (Tan), St. Michael’s Hospital, Toronto, Ont.; J.D. MacLean Centre for Tropical Diseases (Yansouni), Division of Infectious Diseases, Department of Medical Microbiology, McGill University Health Centre, McGill University, Montréal, Que.; Department of Internal Medicine (Zarychanski), Sections of Hematology and Medical Oncology, and Critical Care, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Man.; Division of Infectious Diseases (Murthy), Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC
MD MSc
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Robert Fowler
MDCM MS
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Ruxandra Pinto
PhD
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Alain Tremblay
MDCM
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Sergio Borgia
MSc MD
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François M. Carrier
MD MSc
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Matthew P. Cheng
MD SM
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John Conly
MD
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Cecilia T. Costiniuk
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Peter Daley
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Erick Duan
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Madeleine Durand
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Patricia S. Fontela
MD PhD
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George Farjou
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Mike Fralick
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Anna Geagea
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Jennifer Grant
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Yoav Keynan
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Kosar Khwaja
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Nelson Lee
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Todd C. Lee
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Rachel Lim
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Conar R. O’Neil
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Jesse Papenburg
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Makeda Semret
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Michael Silverman
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Wendy Sligl
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Ranjani Somayaji
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Darrell H.S. Tan
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Jennifer L.Y. Tsang
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Jason Weatherald
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Cedric Philippe Yansouni
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Ryan Zarychanski
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Srinivas Murthy
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Article Information

vol. 10 no. 3 E807-E817
DOI 
https://doi.org/10.9778/cmajo.20220077
PubMed 
36199248
History 
  • Published online September 6, 2022.
Copyright & Usage 
© 2022 CMA Impact Inc. or its licensors This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

Author Information

  1. Vincent I. Lau, MD MSc,
  2. Robert Fowler, MDCM MS,
  3. Ruxandra Pinto, PhD,
  4. Alain Tremblay, MDCM,
  5. Sergio Borgia, MSc MD,
  6. François M. Carrier, MD MSc,
  7. Matthew P. Cheng, MD SM,
  8. John Conly, MD,
  9. Cecilia T. Costiniuk, MD MSc,
  10. Peter Daley, MD MSc,
  11. Erick Duan, MD MSc,
  12. Madeleine Durand, MD MSc,
  13. Patricia S. Fontela, MD PhD,
  14. George Farjou, MD,
  15. Mike Fralick, MD PhD,
  16. Anna Geagea, MD,
  17. Jennifer Grant, MDCM,
  18. Yoav Keynan, MD PhD,
  19. Kosar Khwaja, MD MBA,
  20. Nelson Lee, MD MBBS,
  21. Todd C. Lee, MD MPH,
  22. Rachel Lim, MD,
  23. Conar R. O’Neil, MD MSc,
  24. Jesse Papenburg, MDCM MSc,
  25. Makeda Semret, MD,
  26. Michael Silverman, MD,
  27. Wendy Sligl, MD MSc,
  28. Ranjani Somayaji, MD MPH,
  29. Darrell H.S. Tan, MD PhD,
  30. Jennifer L.Y. Tsang, MD PhD,
  31. Jason Weatherald, MD MSc,
  32. Cedric Philippe Yansouni, MD,
  33. Ryan Zarychanski, MD MSc,
  34. Srinivas Murthy, MD MSc
  35. for the E-CATCO authors, AMMI Clinical Research Network and Canadian Critical Care Trials Group
  1. Department of Critical Care Medicine (Lau, Sligl), Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, Edmonton, Alta.; Interdepartmental Division of Critical Care Medicine (Fowler), University of Toronto; Department of Critical Care Medicine (Pinto), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Respiratory Medicine (Tremblay, Lim, Weatherald), Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Borgia), William Osler Health System, Brampton, Ont.; Division of Infectious Diseases (Borgia), Department of Medicine, McMaster University, Hamilton, Ont.; Division of Critical Care Medicine (Carrier), Departments of Anesthesiology and Medicine, Centre hospitalier de l’Université de Montréal; Infectious Diseases and Medical Microbiology (Cheng), Department of Medicine, McGill University Health Centre, Montréal, Que.; Section of Infectious Diseases (Conly, Somayaji), Department of Medicine, Cumming School of Medicine, University of Calgary and Alberta Health Services, Calgary, Alta.; Division of Infectious Diseases and Chronic Viral Illness Service (Costiniuk), Department of Medicine, McGill University Health Centre, Montréal, Que.; Department of Medicine and Laboratory Medicine (Daley), Memorial University, St. John’s, NL; Division of Critical Care (Duan, Tsang), Department of Medicine, McMaster University, Hamilton, Ont.; Department of Medicine (Duan, Tsang), Niagara Health, St. Catharines, Ont.; Department of Critical Care (Duan), St. Joseph’s Healthcare, Hamilton, Ont.; Internal Medicine Service (Durand), Centre hospitalier de l’Université de Montréal; Division of Pediatric Critical Care (Fontela), Department of Pediatrics, McGill University, Montréal, Que.; Division of Infectious Disease (Farjou), Department of Medicine, Niagara Health, St. Catharines, Ont.; Department of Medicine (Fralick, Semret), Sinai Health, University of Toronto; Division of Critical Care Medicine (Geagea), Department of Medicine, North York General Hospital, Toronto, Ont.; Division of Medical Microbiology and Infectious Diseases (Grant), Department of Medicine, University of British Columbia, Vancouver, BC; Section of Infectious Diseases (Keynan), Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Man.; Departments of Surgery and Critical Care Medicine (Khwaja), McGill University, Montréal, Que.; Dalla Lana School of Public Health (N. Lee), University of Toronto, Toronto, Ont.; Clinical Practice Assessment Unit (T. Lee), Department of Medicine, McGill University, Montréal, Que.; Division of Infectious Diseases (O’Neil), Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta.; Division of Pediatric Infectious Diseases (Papenburg), Department of Pediatrics, Montreal Children’s Hospital; Division of Microbiology (Papenburg), Department of Clinical Laboratory Medicine, McGill University Health Centre, Montréal, Que.; Division of Infectious Diseases (Silverman), Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont.; Division of Infectious Diseases (Tan), St. Michael’s Hospital, Toronto, Ont.; J.D. MacLean Centre for Tropical Diseases (Yansouni), Division of Infectious Diseases, Department of Medical Microbiology, McGill University Health Centre, McGill University, Montréal, Que.; Department of Internal Medicine (Zarychanski), Sections of Hematology and Medical Oncology, and Critical Care, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Man.; Division of Infectious Diseases (Murthy), Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC
  1. Correspondence to: Vincent Lau, vince.lau{at}ualberta.ca
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Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial
Vincent I. Lau, Robert Fowler, Ruxandra Pinto, Alain Tremblay, Sergio Borgia, François M. Carrier, Matthew P. Cheng, John Conly, Cecilia T. Costiniuk, Peter Daley, Erick Duan, Madeleine Durand, Patricia S. Fontela, George Farjou, Mike Fralick, Anna Geagea, Jennifer Grant, Yoav Keynan, Kosar Khwaja, Nelson Lee, Todd C. Lee, Rachel Lim, Conar R. O’Neil, Jesse Papenburg, Makeda Semret, Michael Silverman, Wendy Sligl, Ranjani Somayaji, Darrell H.S. Tan, Jennifer L.Y. Tsang, Jason Weatherald, Cedric Philippe Yansouni, Ryan Zarychanski, Srinivas Murthy
Jul 2022, 10 (3) E807-E817; DOI: 10.9778/cmajo.20220077

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Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial
Vincent I. Lau, Robert Fowler, Ruxandra Pinto, Alain Tremblay, Sergio Borgia, François M. Carrier, Matthew P. Cheng, John Conly, Cecilia T. Costiniuk, Peter Daley, Erick Duan, Madeleine Durand, Patricia S. Fontela, George Farjou, Mike Fralick, Anna Geagea, Jennifer Grant, Yoav Keynan, Kosar Khwaja, Nelson Lee, Todd C. Lee, Rachel Lim, Conar R. O’Neil, Jesse Papenburg, Makeda Semret, Michael Silverman, Wendy Sligl, Ranjani Somayaji, Darrell H.S. Tan, Jennifer L.Y. Tsang, Jason Weatherald, Cedric Philippe Yansouni, Ryan Zarychanski, Srinivas Murthy
Jul 2022, 10 (3) E807-E817; DOI: 10.9778/cmajo.20220077
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