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SARS-CoV-2 testing, infection and outcomes among Ontario physicians: a descriptive population-based cohort study

Cheng-Wei Liu, Nivethika Jeyakumar, Eric McArthur, Jessica M. Sontrop, Daniel T. Myran, Kevin L. Schwartz, Manish M. Sood, Peter Tanuseputro and Amit X. Garg
July 19, 2022 10 (3) E657-E665; DOI: https://doi.org/10.9778/cmajo.20210263
Cheng-Wei Liu
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Nivethika Jeyakumar
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Eric McArthur
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Jessica M. Sontrop
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Daniel T. Myran
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Kevin L. Schwartz
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Manish M. Sood
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Peter Tanuseputro
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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Amit X. Garg
ICES Jeyakumar, McArthur, Garg, Myran, Sood, Tanuseputro, Schwartz, Ont.; Department of Medicine (Liu, Garg), Western University, London, Ont.; Department of Epidemiology & Biostatistics (Sontrop, Garg), Western University, London, Ont.; Clinical Epidemiology Program (Myran, Sood, Tanuseputro), Ottawa Hospital Research Institute, Ottawa, Ont.; Public Health Ontario (Schwartz); Dalla Lana School of Public Health (Schwartz), University of Toronto, Toronto, Ont.; Department of Medicine (Sood, Tanuseputro) and Department of Family Medicine (Myran), University of Ottawa, Ottawa, Ont.
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  • Figure 1:
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    Figure 1:

    Physician cohort build. *Physicians whose permanent address was outside of Ontario were considered to be non-Ontario residents. The province where a person’s permanent address is located is encoded by the first 2 digits of the variable “prcddablk” in the Registered Persons Database, and the first 2 digits, “35,” represent Ontario. If data for this variable were missing or if the first 2 digits were not 35, the physician was considered to be a non-Ontario resident. Similarly, physicians with no registered health care services in the previous 5 years were considered to be non-Ontario residents.

  • Figure 2:
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    Figure 2:

    Trends in SARS-CoV-2 testing and infection during the study period. Note: On May 2, 2020, Ontario shifted from a test-based approach (2 consecutive negative tests collected at least 24 hr apart) to a time-based approach (waiting 14 d from a positive test) for clearing cases. (23) Biweekly testing was mandated for workers in long-term care (LTC) homes on May 31, 2020, (24) which changed to weekly testing in hotspots on Nov. 22, 2020. (25)

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    Figure 3:

    Testing for SARS-CoV-2 infection among physicians who provided care in long-term care (LTC) settings versus other settings, by week. Note: On May 2, 2020, Ontario shifted from a test-based approach (2 consecutive negative tests collected at least 24 h apart) to a time-based approach (waiting 14 d from a positive test) for clearing cases. (23) Biweekly testing was mandated for workers in LTC homes on May 31, 2020, (24) which changed to weekly testing in hotspots on Nov. 22, 2020. (25)

Tables

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    Table 1:

    Baseline characteristics of 41 208 physicians who practised in Ontario in 2020

    CharacteristicNo. (%)* of physicians
    n = 41 208
    Age, yr, mean ± SD46.6 ± 14.1
     < 4015956 (38.7)
     40–5916422 (39.9)
     ≥ 608830 (21.4)
    Sex
     Male23102 (56.1)
     Female18106 (43.9)
    Residence†
     Urban39265 (95.3)
     Rural1758 (4.3)
     Missing185 (0.4)
    Local Health Integration Network‡
     Toronto Central9934 (24.1)
     Central5323 (12.9)
     Champlain5185 (12.6)
     Hamilton Niagara Haldimand Brant4292 (10.4)
     Mississauga Halton3372 (8.2)
     South West3343 (8.1)
     South East1868 (4.5)
     Central East1774 (4.3)
     Waterloo Wellington1441 (3.5)
     North East1251 (3.0)
     Erie St. Clair1121 (2.7)
     North Simcoe Muskoka974 (2.4)
     Central West738 (1.8)
     North West592 (1.4)
    Specialty
     Family medicine18553 (45.0)
     Surgical4393 (10.7)
     Internal medicine3499 (8.5)
     Anesthesia1295 (3.1)
     Emergency478 (1.2)
     Cardiology363 (0.9)
     Infectious diseases67 (0.2)
     Postgraduate medical trainee4125 (10.0)
     Other specialty6462 (15.7)
     Missing1973 (4.8)
    Provided care in a long-term care home
     No38918 (94.4)
     Yes2290 (5.6)
    Medical school location
     Canada27479 (66.7)
     International13729 (33.3)
    Years since medical school graduation, mean ± SD20.6 ± 14.3
    Hospital admissions§
     ≥ 115750 (38.2)
    Charlson Comorbidity Index§
     Mean score ± SD0.1 ± 0.5
     013942 (88.5)
     ≥ 11808 (11.5)
    • Note: CPSO = College of Physicians and Surgeons of Ontario, SD = standard deviation.

    • ↵* Unless otherwise specified.

    • ↵† Rural defined as residing in a location with a population of < 10 000 individuals.

    • ↵‡ Residence within Local Health Integration Network regions as defined by the Ontario Ministry of Health. Physician’s residential location may not coincide with their practice location. For a map, see https://www150.statcan.gc.ca/n1/pub/82-003-x/2015003/article/14144/c-g/fig1-eng.htm.

    • ↵§ Calculated using all hospital admission records in the 5-year period before the study entry date. We defined the study entry date as Jan. 25, 2020, for physicians registered in CPSO by this date, and for those who registered after Jan. 25, 2020, the CPSO registration date was used as the study entry date.

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    Table 2:

    SARS-CoV-2 testing and infection in 41 208 physicians who practised in Ontario in 2020

    CharacteristicNo. of physiciansNo. (row %) of physicians testedNo. (row %) of physicians who tested positiveProportion of total physicians
    n = 41 208
    Proportion of physicians tested
    n = 19 116
    Proportion of physicians testing positive
    n = 358
    Overall41 20819116 (46.4)358 (0.9)
    Age, yr
     < 4015 9568707 (54.6)167 (1.0)38.745.546.6
     40–5916 4227191 (43.8)123 (0.7)39.937.634.4
     ≥ 6088303218 (36.4)68 (0.8)21.416.819.0
    Sex
     Male23 1029995 (43.3)213 (0.9)56.152.359.5
     Female18 1069121 (50.4)145 (0.8)43.947.740.5
    Residence*
     Urban39 26518 127 (46.2)≥ 352 (≥ 0.9)95.294.8≥ 98.3
     Rural1758908 (51.6)< 6 (< 0.3)4.34.7< 1.7
     Missing18581 (43.8)0 (0)0.40.40
    Local Health Integration Network†
     Toronto Central99345088 (51.2)112 (1.1)24.126.631.3
     Central53232248 (42.2)50 (0.9)12.911.814.0
     Champlain51852399 (46.3)28 (0.5)12.612.57.8
     Hamilton Niagara Haldimand Brant42921983 (46.2)40 (0.9)10.410.411.2
     Mississauga Halton33721551 (46.0)42 (1.2)8.28.111.7
     South West33431593 (47.7)19 (0.6)8.18.35.3
     South East1868712 (38.1)< 6 (< 0.3)4.53.7< 1.7
     Central East1774781 (44.0)18 (1.0)4.34.15.0
     Waterloo Wellington1441635 (44.1)18 (1.2)3.53.35.0
     North East1251626 (50.0)< 6 (< 0.5)3.03.3< 1.7
     Erie St. Clair1121410 (36.6)9 (0.8)2.72.12.5
     North Simcoe Muskoka974433 (44.5)7 (0.7)2.42.32.0
     Central West738299 (40.5)9 (1.2)1.81.62.5
     North West592358 (60.5)< 6 (< 1.0)1.41.9< 1.7
    Specialty
     Family medicine18 5538857 (47.7)171 (0.9)45.046.347.8
     Surgical43931679 (38.1)22 (0.5)10.78.86.1
     Internal medicine34991625 (46.4)44 (1.3)8.58.512.3
     Anesthesia1295596 (46.0)6 (0.5)3.13.11.7
     Emergency478281 (58.8)< 6 (< 1.3)1.21.5< 1.7
     Cardiology363161 (44.4)< 6 (< 1.7)0.90.8< 1.7
     Postgraduate medical trainee41252531 (61.4)47 (1.1)0.113.213.1
     Infectious diseases6733 (49.3)< 6 (< 9.0)0.20.2< 1.7
     Other specialty64622516 (38.9)≥ 36 (≥ 0.6)15.713.2≥ 10.1
     Missing1973837 (42.4)14 (0.7)4.84.43.9
    Provided care in a long-term care home
     No38 91817 480 (44.9)333 (0.9)94.491.493.0
     Yes22901636 (71.4)25 (1.1)5.68.67.0
    Medical school location
     Canada27 47913 440 (48.9)230 (0.8)66.770.364.2
     International13 7295676 (41.3)128 (0.9)33.329.735.8
    Hospital admissions‡
     ≥ 115 7507735 (49.1)133 (0.8)38.240.537.2
    Charlson Comorbidity Index score‡
     013 9426975 (50.0)119 (0.9)88.590.289.5
     ≥ 11808760 (42.0)14 (0.8)11.59.810.5
    • Note: CPSO = College of Physicians and Surgeons of Ontario, SD = standard deviation.

    • ↵* Rural was defined as residing in a location with a population of < 10 000 individuals.

    • ↵† Residence within Local Health Integration Network regions as defined by the Ontario Ministry of Health. Physician’s residential location may not coincide with their practice location. For a map, see https://www150.statcan.gc.ca/n1/pub/82-003-x/2015003/article/14144/c-g/fig1-eng.htm.

    • ↵‡ Calculated using all hospital admission records in the 5-year period before study entry date. The study entry date was defined as Jan. 25, 2020, for physicians registered in CPSO on or before this date, and it was defined as the CPSO registration date for those who entered the cohort after this date.

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SARS-CoV-2 testing, infection and outcomes among Ontario physicians: a descriptive population-based cohort study
Cheng-Wei Liu, Nivethika Jeyakumar, Eric McArthur, Jessica M. Sontrop, Daniel T. Myran, Kevin L. Schwartz, Manish M. Sood, Peter Tanuseputro, Amit X. Garg
Jul 2022, 10 (3) E657-E665; DOI: 10.9778/cmajo.20210263

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SARS-CoV-2 testing, infection and outcomes among Ontario physicians: a descriptive population-based cohort study
Cheng-Wei Liu, Nivethika Jeyakumar, Eric McArthur, Jessica M. Sontrop, Daniel T. Myran, Kevin L. Schwartz, Manish M. Sood, Peter Tanuseputro, Amit X. Garg
Jul 2022, 10 (3) E657-E665; DOI: 10.9778/cmajo.20210263
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