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Open Access

Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study

Maala Bhatt, Amy C. Plint, Ken Tang, Richard Malley, Anne Pham Huy, Candice McGahern, Jennifer Dawson, Martin Pelchat, Lauren Dawson, Terry Varshney, Corey Arnold, Yannick Galipeau, Michael Austin, Nisha Thampi, Fuad Alnaji, Marc-André Langlois and Roger L. Zemek
April 12, 2022 10 (2) E357-E366; DOI: https://doi.org/10.9778/cmajo.20220026
Maala Bhatt
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD MSc
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Amy C. Plint
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD MSc
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Ken Tang
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhD
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Richard Malley
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD
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Anne Pham Huy
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD
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Candice McGahern
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
BA
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Jennifer Dawson
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhD
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Martin Pelchat
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhD
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Lauren Dawson
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MSc
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Terry Varshney
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD
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Corey Arnold
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhD
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Yannick Galipeau
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
BSc
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Michael Austin
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD
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Nisha Thampi
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD
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Fuad Alnaji
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
MD
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Marc-André Langlois
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
PhD
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Roger L. Zemek
Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
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Article Information

vol. 10 no. 2 E357-E366
DOI 
https://doi.org/10.9778/cmajo.20220026
PubMed 
35414597
History 
  • Published online April 12, 2022.
Copyright & Usage 
© 2022 CMA Impact Inc. or its licensors This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/

Author Information

  1. Maala Bhatt, MD MSc,
  2. Amy C. Plint, MD MSc,
  3. Ken Tang, PhD,
  4. Richard Malley, MD,
  5. Anne Pham Huy, MD,
  6. Candice McGahern, BA,
  7. Jennifer Dawson, PhD,
  8. Martin Pelchat, PhD,
  9. Lauren Dawson, MSc,
  10. Terry Varshney, MD,
  11. Corey Arnold, PhD,
  12. Yannick Galipeau, BSc,
  13. Michael Austin, MD,
  14. Nisha Thampi, MD,
  15. Fuad Alnaji, MD,
  16. Marc-André Langlois, PhD,
  17. Roger L. Zemek, MD
  1. Department of Pediatrics (Bhatt, Plint, Pham Huy, Varshney, Thampi, Alnaji, Zemek), Children’s Hospital of Eastern Ontario, University of Ottawa; Department of Emergency Medicine (Plint, Alnaji, Zemek), University of Ottawa; Children’s Hospital of Eastern Ontario Research Institute (Tang, McGahern, J. Dawson, L. Dawson, Austin), Ottawa, Ont.; Division of Infectious Diseases (Malley), Boston Children’s Hospital and Harvard Medical School, Boston, Mass.; Department of Biochemistry, Microbiology and Immunology (Pelchat, Arnold, Galipeau, Langlois), Faculty of Medicine, University of Ottawa; University of Ottawa Centre for Infection, Immunity and Inflammation (Pelchat, Langlois); Ottawa Hospital Research Institute (Austin), Ottawa, Ont.
  1. Correspondence to: Maala Bhatt, mbhatt{at}cheo.on.ca
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CMAJ Open: 10 (2)
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Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study
Maala Bhatt, Amy C. Plint, Ken Tang, Richard Malley, Anne Pham Huy, Candice McGahern, Jennifer Dawson, Martin Pelchat, Lauren Dawson, Terry Varshney, Corey Arnold, Yannick Galipeau, Michael Austin, Nisha Thampi, Fuad Alnaji, Marc-André Langlois, Roger L. Zemek
Apr 2022, 10 (2) E357-E366; DOI: 10.9778/cmajo.20220026

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Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study
Maala Bhatt, Amy C. Plint, Ken Tang, Richard Malley, Anne Pham Huy, Candice McGahern, Jennifer Dawson, Martin Pelchat, Lauren Dawson, Terry Varshney, Corey Arnold, Yannick Galipeau, Michael Austin, Nisha Thampi, Fuad Alnaji, Marc-André Langlois, Roger L. Zemek
Apr 2022, 10 (2) E357-E366; DOI: 10.9778/cmajo.20220026
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