Cumulative risk of being diagnosed with an infection-related cancer by age 65 years for people with and without HIV infection, by calendar period
| Variable | Cumulative risk, % (95% CI) | |||||
|---|---|---|---|---|---|---|
| People with HIV infection; period | People without HIV infection; period | |||||
| 1996–2003 | 2004–2011 | 2012–2020 | 1996–2003 | 2004–2011 | 2012–2020 | |
| Cancer group | ||||||
| All cancers | 25.3 (21.6–29.1) | 25.6 (22.5–28.8) | 18.3 (16.1–20.5) | 11.0 (5.9–10.1) | 14.2 (9.3–9.3) | 13.9 (12.5–15.2) |
| Infection-unrelated cancer | 7.0 (4.8–9.3) | 9.4 (7.4–11.4) | 8.7 (7.6–9.7) | 10.8 (5.7–15.9) | 12.4 (10.2–14.6) | 11.8 (10.5–13.1) |
| Infection-related cancer | 19.0 (15.6–22.3) | 17.0 (14.1–19.9) | 10.0 (7.9–12.1) | 0.2 (0.0–0.4) | 2.0 (0.9–2.9) | 2.2 (1.6–2.8) |
| ADC | 14.8 (11.9–17.7) | 12.0 (9.2–14.8) | 6.0 (4.0–8.1) | 0.2 (0.0–0.4) | 0.5 (0.01–1.1) | 0.8 (0.5–1.2) |
| Infection-related NADC | 5.1 (2.7–7.5) | 5.8 (4.3–7.2) | 4.2 (3.4–5.0) | 0.0 | 1.4 (0.5–2.2) | 1.4 (0.9–1.8) |
| Most common site-specific NADCs among people with HIV infection | ||||||
| Prostate* | 1.7 (0.3–3.1) | 1.2 (0.5–2.0) | 2.1 (1.5–2.8) | 5.9 (1.2–10.6) | 5.5 (3.6–7.3) | 3.4 (2.6–4.2) |
| Lung | 0.9 (0.2–1.6) | 2.6 (1.6–3.6) | 1.5 (1.0–1.9) | 1.7 (0.0–3.6) | 1.0 (0.3–1.7) | 1.4 (0.9–1.9) |
| Colorectal | 1.3 (0.4–2.3) | 0.9 (0.3–1.6) | 1.0 (0.7–1.4) | 2.0 (0.0–4.0) | 1.3 (0.5–2.1) | 1.4 (1.0–1.8) |
| Anal | 1.9 (0.6–3.1) | 1.3 (0.7–2.0) | 1.8 (1.3–2.3) | 0.0 | 0.03 (0.0–0.1) | 0.02 (0.0–0.1) |
| Liver | 1.1 (0.0–2.3) | 0.7 (0.3–1.2) | 0.6 (0.3–0.9) | 0.0 | 0.4 (0.0–0.9) | 0.3 (0.1–0.5) |
| Sex | ||||||
| Female | ||||||
| Infection-unrelated cancer | 6.6 (2.4–10.8) | 11.4 (7.1–15.7) | 10.2 (7.7–12.6) | 4.4 (0.8–8.1) | 8.4 (4.5–12.3) | 13.2 (10.4–16.0) |
| Infection-related cancer | 9.7 (4.9–14.4) | 8.9 (5.5–12.3) | 6.4 (4.3–8.5) | 0.5 (0.0–1.5) | 1.7 (0.0–4.1) | 0.9 (0.3–1.6) |
| Male | ||||||
| Infection-unrelated cancer | 7.4 (4.7–10.1) | 9.4 (6.4–12.4) | 8.3 (7.1–9.4) | 12.2 (6.0–18.4) | 13.0 (10.5–15.5) | 11.4 (10.0–12.8) |
| Infection-related cancer | 20.2 (16.3–24.0) | 18.2 (14.2–22.3) | 10.7 (8.0–13.3) | 0.1 (0.0–0.3) | 1.9 (0.7–3.1) | 2.2 (1.6–2.9) |
Note: ADC = AIDS-defining cancer, CI = confidence interval, NADC = non–AIDS defining cancer.
↵* Restricted to males.