RT Journal Article
SR Electronic
T1 Clinical characteristics, multiorgan dysfunction and outcomes of patients with COVID-19: a prospective case series
JF CMAJ Open
JO CMAJ
FD Canadian Medical Association
SP E675
OP E684
DO 10.9778/cmajo.20210151
VO 10
IS 3
A1 Honarmand, Kimia
A1 Fiorini, Kyle
A1 Chakraborty, Debarati
A1 Gillett, Daniel
A1 Desai, Karishma
A1 Martin, Claudio
A1 Bosma, Karen J.
A1 Slessarev, Marat
A1 Ball, Ian M.
A1 Mele, Tina
A1 LeBlanc, Danielle
A1 Elsayed, Sameer
A1 Lazo-Langner, Alejandro
A1 Nicholson, Mike J.
A1 Arntfield, Robert
A1 Basmaji, John
YR 2022
UL http://www.cmajopen.ca/content/10/3/E675.abstract
AB Background: Characterizing the multiorgan manifestations and outcomes of patients hospitalized with COVID-19 will inform resource requirements to address the long-term burden of this disease. We conducted a descriptive analysis using prospectively collected data to describe the clinical characteristics and spectrum of organ dysfunction, and in-hospital and longer-term clinical outcomes of patients hospitalized with COVID-19 during the first wave of the pandemic at a Canadian centre.Methods: We conducted a prospective case series involving adult patients (aged ≥ 18 yr) with COVID-19 admitted to 1 of 2 hospitals in London, Ontario, from Mar. 17 to June 18, 2020, during the first wave of the pandemic. We recorded patients’ baseline characteristics, physiologic parameters, measures of organ function and therapies administered during hospitalization among patients in the intensive care unit (ICU) and in non-ICU settings, and compared the characteristics of hospital survivors and nonsurvivors. Finally, we recorded follow-up thoracic computed tomography (CT) and echocardiographic findings after hospital discharge.Results: We enrolled 100 consecutive patients (47 women) hospitalized with COVID-19, including 32 patients who received ICU care and 68 who received treatment in non-ICU settings. Respiratory sequelae were common: 23.0% received high-flow oxygen by nasal cannula, 9.0% received noninvasive ventilation, 24.0% received invasive mechanical ventilation and 2.0% received venovenous extracorporeal membrane oxygenation. Overall, 9.0% of patients had cerebrovascular events (3.0% ischemic stroke, 6.0% intracranial hemorrhage), and 6.0% had pulmonary embolism. After discharge, 11 of 19 patients had persistent abnormalities on CT thorax, and 6 of 15 had persistent cardiac dysfunction on echocardiography.Interpretation: This study provides further evidence that COVID-19 is a multisystem disease involving neurologic, cardiac and thrombotic dysfunction, without evidence of hepatic dysfunction. Patients have persistent organ dysfunction after hospital discharge, underscoring the need for research on long-term outcomes of COVID-19 survivors.