RT Journal Article
SR Electronic
T1 Case–control study of household contacts to examine immunological protection from <em>Bordetella pertussis</em> transmission — study protocol
JF CMAJ Open
FD Canadian Medical Association
SP E872
OP E877
DO 10.9778/cmajo.20170072
VO 5
IS 4
A1 Bolotin, Shelly
A1 Johnson, Caitlin
A1 Quach, Susan
A1 Ambrose, Ardith
A1 DeCoutere, Sarah
A1 Deeks, Shelley L.
A1 Drews, Steven
A1 Faheem, Amna
A1 Green, Karen
A1 Halperin, Scott A.
A1 Hoang, Linda
A1 Jamieson, Frances
A1 Kollmann, Tobias
A1 Marchand-Austin, Alex
A1 McCormack, Deirdre
A1 McGeer, Allison
A1 Murti, Michelle
A1 BBA, Alison Orth
A1 Rebbapragada, Anu
A1 Vanderkooi, Otto G.
A1 Wang, Jun
A1 Warshawsky, Bryna
A1 Crowcroft, Natasha S.
A1 for the Canadian Immunization Research Network Provincial Collaborative Network
YR 2017
UL http://www.cmajopen.ca/content/5/4/E872.abstract
AB Background: There is mounting evidence that the recent resurgence of pertussis in many countries is in part related to the acellular vaccine, which has been administered in Canada since 1997. This vaccine elicits a different cell-mediated immune response than the previously used whole-cell vaccine, and its effectiveness wanes over time. The aim of this study is to understand the immunological, demographic and clinical factors that mediate protection from pertussis on exposure.Methods: This is a household case-control study protocol. Following notification of an index case in a household, a study team will conduct a home visit to collect data and biological specimens. The study team will return to the household 8 weeks from the onset of illness in the index case. The Th1, Th2 and Th17 responses, cytokine expression, IgG subclass, blood cell counts and presence of Bordetella pertussis will be determined. We will use laboratory and statistical analyses to determine immunological differences between contacts who are infected with B. pertussis and contacts who remain healthy, and to determine which clinical and demographic covariates are associated with a reduced risk of infection.Interpretation: The results of this study will be essential for understanding the immune response required for protection from infection with B. pertussis and will contribute to our understanding of the shortcomings of the current vaccine.